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The majority of newly diagnosed children by NBS is asymptomatic or mildly affected because of relative high residual enzyme activity [22, 60, 121]

Immune System Function Your immune cells, particularly T-cells, require adequate glutathione to function correctly

Data and code availability The code generated during this study is available at METHOD DETAILS Hepatocyte specific model Starting with the thermodynamically curated human genome-scale Recon 3D 31,32 , we reconstructed a hepatocyte metabolic model by taking into account the physiology of hepatocytes and the genes expressed in liver cells